Neuropathy Treatments

Treatments of Neuropathy

Introduction

Symptoms

Different causes

Diagnosis

Treatments of Neuropathy

Testimonials and Reviews

Polyneuropathy:

Since polyneuropathy is generally caused by a systemic illness, we need to find and treat the underlying disease process.  The treatment of neuropathy and its success depends on the underlying illness that is causing it.  Unfortunately there is not a single treatment that works for all neuropathies. Each type of neuropathy has its own unique treatment.

Diabetic Neuropathy

Diabetic Neuropathy could be a complex problem but it is often a treatable neuropathy. One of the first steps in the treatment is to get good control of glucose levels, which could slow the progression of the neuropathy. However we find that this is often not enough.  Patient could have good control of their glucose levels and yet their neuropathy could progress. We often find that diabetic patients generally have a second disease process that is affecting the nerves. It appears that the nerves in diabetic patients become more sensitive to injury.  Disease processes that would cause minor injury to the nerves of non-diabetic patients could have more of an effect in diabetic patients. We often find that when we treat the secondary disease process that the patients could have significant relief.

One of the common processes that we see in diabetics is entrapment syndromes.  The nerves in the body generally pass through tunnels that are made of muscles and tendons. If the tunnel becomes narrow or the nerve swells, then the nerve could become entrapped. Diabetic patients could have swelling of the nerves which causes entrapment.  The most common one is carpal tunnel syndrome which is the entrapment of the nerves that pass through the tendons of the wrist.  This causes hand pain, tingling, burning, and numbness (See carpal tunnel syndrome). We have been finding that the same kind of process could occur in the legs. The nerves in the legs could become entrapped in the tendons that they pass through. There are very simple surgical techniques available that are able to release the nerve from the tunnel.  We find that once the entrapped nerve is released the patients get significant relief, even from severe pain and burning.

Another category of problems we see in patients that have diabetic neuropathy are vitamin deficiencies or excess levels of vitamins.   We often see that once we correct the vitamin levels, the patient could find significant relief.

In some of our diabetic patients we find that they have an immune mediated neuropathy (see below for more details). 

We have just mentioned some of the common problems we see as secondary problems in diabetic patients.  There are multiple other disease processes that need to be looked at as well.  We find that once we have the proper diagnosis, most diabetic neuropathies have treatment. 

Vitamin deficiencies and vitamin excess

Another category of diseases that we see are vitamin deficiencies and vitamin excess.   With more accurate testing we are finding that a significant portion of our patients have vitamin abnormalities. We not only measure the body’s vitamin levels directly, but we use tests that indicate how the body is using the vitamins.  These tests show that some patients might need a change in their levels of vitamins even though they could have near normal blood levels of the vitamin itself.  This is because different bodies handle different vitamin levels differently. In one patient a certain vitamin level might be enough but in another a higher level of vitamins might be needed.  The vitamins that are known to effect nerves include vitamin B6, B12, B1, and Folic acid. Once the patient gets the proper amount of vitamins they could have significant improvement.

CIDP and Immune Mediate Neuropathies

CIDP is a disease process by which body’s own immune system attacks its own nerves (see CIDP for more information). There are now very good treatments to stop the immune system from attacking its own nerves.  Once the immune system stops attacking the nerves, this allows the nerves to regenerate.  Even patients who have CIDP with severe weakness, numbness, tingling, or burning could have very good response to these treatments. In addition to treating the underlying disease, we use different techniques to control the symptoms including multiple different medications, physical therapy, braces, electrical stimulators, surgical methods, and injections. 

We have just mentioned some of the common neuropathies we see and their treatments.  There are multiple other disease processes that need to be looked at as well. 

Mononeuropathy:

Generally when a single nerve of the body is not working properly there is a local cause for it.  By finding that part of the nerve that is not working, an attempt is made to relieve the local cause.  This could be done by wearing the proper brace, physical therapy, medications, being aware and using the correct posture, and at times surgical intervention is needed to prevent further damage of the nerve and even reverse the symptoms.  If proper treatments are not provided and the problem is ignored, the disease could progress and the injury could become irreversible.

References

  1. Huang CR, Chang WN, Tsai NW, Lu CH. Serial nerve conduction studies in vitamin B12 deficiency-associated polyneuropathy. Neurol Sci. 2011 Feb;32(1):183-6. Epub 2010 Oct 2.
  2. Ahmed A, Kothari MJ. Recovery of neurologic dysfunction with early intervention of vitamin B12. J Clin Neuromuscul Dis. 2010 Jun;11(4):198-202.
  3. Nardin RA, Amick AN, Raynor EM. Vitamin B(12) and methylmalonic acid levels in patients presenting with polyneuropathy. Muscle Nerve. 2007 Oct;36(4):532-5.
  4. Tackenberg B, Nimmerjahn F, Lünemann JD.Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy.J Clin Immunol. 2010 May;30 Suppl 1:S65-9.
  5. England JD, Gronseth GS, et al. Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrod. PM R. 2009 Jan;1(1):14-22.
  6. Greet Hermans, Bernard De Jonghe, et al. Clinical review: Critical illness polyneuropathy and myopathy. Crit Care. 2008; 12(6): 238.
  7. Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006832.
  8. Wolfgang Zink, Rainer Kollmar & Stefan Schwab. Critical illness polyneuropathy and myopathy in the intensive care unit. Nature Reviews Neurology 5, 372-379 (July 2009) | doi:10.1038/nrneurol.2009.75
  9. Jian-bo L, Cheng-ya W, Jia-wei C, Xiao-lu L, Zhen-qing F, Hong-tai M. The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels. Nutr Neurosci. 2010 Apr;13(2):79-86.
  10. Bell, David S.H. MD. Metformin-Induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy. Southern Medical Journal:March 2010 - Volume 103 - Issue 3 - pp 265-267
  11. Daryl J. Wile, MD, and Cory Toth, MD. Association of metformin, elevated homocysteine and methylmalonic acid levels, and clinically worsened diabetic peripheral neuropathy. Diabetes Care. 2010 Jan;33(1):134-61. Epub 2009 Oct 21.
  12. S Jann, M A Bramerio, D Facchetti, R Sterzi. Intravenous immunoglobulin is effective in patients with diabetes and with chronic inflammatory demyelinating polyneuropathy: long term follow-up. J Neurol Neurosurg Psychiatry 2009;80:70-73 doi:10.1136/jnnp.2008.149013.
  13. D. Ram Ayyar and Khema R. Sharma. Chronic inflammatory demyelinating polyradiculoneuropathy in diabetes mellitus. Current Diabetes ReportsVolume 4, Number 6, 409-412, DOI: 10.1007/s11892-004-0048-y
Neurology Muscular Dystrophy and Neuropathy Specialist
9301 Wilshire Blvd. Suite 600, Beverly Hills (Los Angeles County), CA 90210
(310) 278-2525
 
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